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JP5778735B2 Use of pyrimidine derivatives for the Egfr

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2 - (2, 4, 5 - SUBSTITUTED -ANILINO) PYRIMIDINE DERIVATIVES AS EGFR MODULATORS USEFUL FOR TREATING CANCER by AstraZeneca AB – AU 20152616

Get details on patent AU2015261672 - 2 - (2, 4, 5 - SUBSTITUTED -ANILINO) PYRIMIDINE DERIVATIVES AS EGFR MODULATORS USEFUL FOR TREATING CANCER by AstraZeneca AB and more at IP in Australia ... Abstract The present invention relates to ...

Discovery of 5-(methylthio)pyrimidine derivatives as L858R/T790M mutant selective epidermal growth factor receptor (EGFR) inhibitor

Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. ... View This Abstract Online Discovery of 5-(methylthio)pyrimidine derivatives as L858R/T790M mutant ...

JP5778735B2 - Use of pyrimidine derivatives for the Egfr dependent diseases or egfr family members to treat diseases that have acquired resistance .

JP5778735B2 - Use of pyrimidine derivatives for the Egfr dependent diseases or egfr family members to treat diseases that have acquired resistance to agents that target ... JP5778735B2 JP2013206606A JP2013206606A JP5778735B2 JP 5778735 B2 JP5778735 ...

Urea Cycle Sustains Cellular Energetics upon EGFR Inhibition in EGFR-Mutant NSCLC | Molecular Cancer Resear

EGFR signaling has been linked to the rewiring of tumor metabolism in non–small cell lung cancer (NSCLC). ... We show that EGFR inhibition and CPS1 knockdown lead to a decrease in arginine levels and pyrimidine derivatives, and the addition of exogenous ...

Discovery of 7-bromo-1,4-dihydrothieno[3’,2’:5,6]thiopyrano[4,3-c]pyrazole-3-carboxamide derivatives as the potential epidermal growth factor .

Abstract Small molecule tyrosine kinase inhibitors (TKIs) targeting at epidermal growth factor receptor (EGFR) in recent years have made great progress in the treatment of advanced non-small cell cancer (NSCLC). Although as the first-line treatment for sensitizing ...

Osimertinib - Wikiped

Medical uses Osimertinib is used to treat locally advanced or metastatic non-small-cell lung cancer (NSCLC), if the cancer cells are positive for the T790M mutation in the gene coding for EGFR. The T790M mutation may be de novo or acquired following first-line ...

EP2599499A1 - Use of pyrimidine derivatives for the treatment of EGFR dependent diseases or diseases that have acquired resistance to agents that .

of said compounds with EGFR modulators for said use, methods of treating said diseases with said compounds and pharmaceutical preparations for the treatment of said diseases comprising said compounds alone or in combination, especially ...

Structure-Activity Relationship of Indole-Tethered Pyrimidine Derivatives that Concurrently Inhibit Epidermal Growth Factor Receptor and Other .

Herein, we describe the synthesis and evaluation of pyrimidine derivatives that inhibit EGFR while retaining their inhibitory activity for angiokinases, and determined their structure-activity relationship (SAR). Materials and Methods ...

USE OF PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF EGFR DEPENDENT DISEASES OR DISEASES THAT HAVE ACQUIRED RESISTANCE TO AGENTS THAT TARGET EGFR .

Patent View for US2011033453 USE OF PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF EGFR DEPENDENT DISEASES OR DISEASES THAT HAVE ACQUIRED RESISTANCE TO AGENTS THAT TARGET EGFR FAMILY MEMBERS Contents Email ...

Erlotinib - Wikiped

Erlotinib hydrochloride (trade name Tarceva) is a drug used to treat non-small cell lung cancer, pancreatic cancer and several other types of cancer. It is a receptor tyrosine kinase inhibitor, which acts on the epidermal growth factor receptor (EGFR).

Structure-Activity Relationship of Indole-Tethered Pyrimidine Derivatives that Concurrently Inhibit Epidermal Growth Factor Receptor and Other .

Structure-Activity Relationship of Indole-Tethered Pyrimidine Derivatives that Concurrently Inhibit Epidermal Growth Factor Receptor and Other Angiokinases Jiho Song, 1 Jakyung Yoo, 2 Ara Kwon, 1 Doran Kim, 1 Hong Khanh Nguyen, 1 Bong-Yong Lee, 2 , 1, * ...

Pyrimidine-urea derivatives as kinase inhibito

a signal transfer inhibitor selected from antibodies a target of which is EGFR receptor; tyrosine kinase EGFR inhibitors; ... SUBSTANCE: invention relates to novel imidazole derivatives of general formula I and pharmaceutically acceptable salts thereof 1 2 ...

Novel Synthesis Approach and Antiplatelet Activity Evaluation of 6-Arylmethyleneamino-2-Alkylsulfonylpyrimidin-4(3H)-one Derivatives and Its .

potentially increased the EGFR inhibitory effect [20,21]. According to the results observed with the former pyrimidine derivatives as platelet antiaggregating agents ...

Unraveling structural requirements of amino-pyrimidine T790M/L858R double mutant EGFR inhibitors: 2D and 3D QSAR study: Journal of Receptors and .

In this study, various 2 D and 3 D Quantitative Structure–Activity Relationship models were built for amino-pyrimidine compounds with their known biological activity against TMLR mutants.

Molecular modeling study bioactive natural product of khellin analogues as a novel potential pharmacophore of EGFR inhibito

Activation of EGFR may be because of overex-pression, mutations resulting in constitutive activation, ... Many chromone-pyrimidine derivatives are acknowledged to possess a wide range of bioactivities. The furochromone-pyridines 4 and 5 motif makes up the ...

Targeting non-small cell lung cancer with small-molecule EGFR tyrosine kinase inhibitors, Drug Discovery Today | 10.1016/j.drudis.2017.10.004 .

Novel 2-chloro-4-anilino-quinazoline derivatives as EGFR and VEGFR-2 dual inhibitors Barbosa, M.L.D.C. ... All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can ...

EP 3009431 A1 20160420 - 2-(2,4,5-SUBSTITUTED-ANILINO)PYRIMIDINE DERIVATIVES AS EGFR MODULATORS USEFUL FOR TREATING CANC

450439942 - EP 3009431 A1 2016-04-20 - 2-(2,4,5-SUBSTITUTED-ANILINO)PYRIMIDINE DERIVATIVES AS EGFR MODULATORS USEFUL FOR TREATING CANCER ...

Surmounting the resistance against EGFR inhibitors through the development of thieno[2,3-d]pyrimidine-based dual EGFR/HER2 inhibitors - ScienceDire

A series of thieno[2,3-d]pyrimidine-based dual EGFR/HER2 inhibitors was developed. • Screening for the optimum aniline headgroup for dual inhibition identified 21. • Optimizing the solubilizing group of ...

Patents | Charles River Discovery Servic

2019 Patents Pyrimidine Derivatives And Their Use Use For The Treatment Of Cancer. WO/2019/122932 Azaindole Derivatives As Rho-Kinase Inhibitors. ...

Frontiers | Design, Synthesis, and Evaluation of Ribose-Modified Anilinopyrimidine Derivatives as EGFR Tyrosine Kinase Inhibitors | Chemist

The synthesis of a series of ribose-modified anilinopyrimidine derivatives was efficiently achieved by utilizing DBU or tBuOLi-promoted coupling of ribosyl alcohols ...