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Targeting the RNA m6A reader YTHDF2 selectively

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Addition of m6A to SV40 late mRNAs enhances viral structural gene expression and replicati

Targeting the sites of addition of m6A on SV40 mRNAs, using mutagenesis, therefore reduces SV40 replication, ... Here, we first demonstrate that overexpression of the key m 6 A reader protein YTHDF2 induces more rapid viral replication, and larger viral while ...

RNA Epigenetics | The Scientist Magazine

In 2014, for example, we (C.H. and colleagues) showed that the human YTH domain family 2 (YTHDF2) reader protein selectively recognizes m 6 A and mediates mRNA degradation. 7 We identified more than 3,000 cellular RNA targets of YTHDF2, most of which are mRNAs.

MicroRNA-145 Modulates N6-Methyladenosine Levels by Targeting the 3′-Untranslated mRNA Region of the N6-Methyladenosine Binding YTH Domain .

In this study we present a model that miR-145 modulates m 6 A reader protein YTHDF2 through targeting its mRNA 3′-UTR, leading to the increase of mRNA methylation in HCC cells (Fig. 7D). ...

E-GEOD-49339 - m6A-dependent regulation of messenger RNA stability - Omics

We further estabilshed the role of YTHDF2 in RNA metabolism by a combination of ribosome profiling, RNA sequencing, ... the C-terminal domain of YTHDF2 selectively binds to m6A of mRNA and the N-terminal domain is responsive for localizing mRNA from ...

Targeting the RNA m6A reader YTHDF2 selectively compromises cancer stem cells in acute myeloid leukemia - Edinburgh Research Explor

Acute myeloid leukemia (AML) is an aggressive clonal disorder of hematopoietic stem cells (HSCs) and primitive progenitors that blocks their myeloid differentiation generating self-renewing leukemic stem cells (LSCs). Here we show that the mRNA m 6 A reader ...

Disease-triggering Protein a Potential Achilles' Heel of Blood Cancer | Technology Networ

Further tests enabled scientists to determine the biological pathway by which interfering with the function of YTHDF2 selectively kills blood cancer cells. ...

Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia - ScienceDire

Targeting the RNA m 6 A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia Author links open overlay panel Jasmin Paris 1 2 9 Marcos Morgan 1 3 4 9 Joana Campos 1 ...

Publications: David Wotherspo

Paris J, Morgan M, Campos J, Spencer GJ, Shmakova A, Ivanova I, Mapperley C, Lawson H et al.(2019). Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia. Cell Stem Cell vol. 25, (1) 137-148.e6.

RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3 | SpringerLi

Methylation in the vicinity of stop codons hinted us that the m6A reader YTHDF2 might participate in the regulation of m6A-methylated BNIP3 mRNA stability []. YTHDF2 selectively bound to the N-terminal domain of m6A-containing mRNA and located the]. ...

Suppression of m 6 A reader Ythdf2 promotes hematopoietic stem cell expansion | Cell Resear

Ivanova, I. et al. The RNA m6A reader YTHDF2 is essential for the post-transcriptional regulation of the maternal transcriptome and oocyte competence. ...

Reading RNA methylation codes through methyl-specific binding protei

RNA stability, YTHDF2, RNA-binding protein, YTH domain *Correspondence to: Chuan He; Email: [email protected] ... YTHDF2 and YTHDF3 were selectively identified using synthetic RNA bait containing m6A.3 We also discovered YTHDF1 with a 6 ...

Richard Gregory | Harvard Catalyst Profiles | Harvard Cataly

... Mazurier F, Somervaille TCP, Gregory RI, O'Carroll D, Kranc KR. Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid ...

Professor Kamil R. Kranc – Cancer Research UK Barts Cent

Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia. Cell Stem Cell (2019) S1934-5909(19)30120-1. PMID: 31031138 Fumarate hydratase (Fh1) is a critical metabolic regulator of haematopoietic stem ...

Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia: Cell Stem Ce

Elimination of cancer stem cells in acute myeloid leukemia (AML) while preserving hematopoiesis is a challenge in leukemia treatment. Paris et al. demonstrate that inactivation of the RNA m6A reader YTHDF2 increases the half-life of m6A-modified transcripts and ...

RNA N6-methyladenosine demethylase FTO promotes breast .

Methylation in the vicinity of stop codons hinted us that the m6A reader YTHDF2 might participate in the regulation of m6A-methylated BNIP3 mRNA stability . YTHDF2 selectively bound to the N-terminal domain of m6A-containing mRNA and located the YTHDF2-mRNA complex to the cellular RNA decay sites . We further investigated whether YTHDF2 ...

m6A mRNA methylation controls the innate immune response to infection by targeting interferon β - omi

of the m6A 'writer' protein METTL3 or 'reader' protein YTHDF2 leads to a dramatic increase in the induction of hundreds of ... -signaling dependent manner. Furthermore, we used m6A-immunoprecipitation, followed by RNA-seq, to map m6A sites on ...

N6-methyladenosine modification and the YTHDF2 reader protein play cell type specific roles in lytic viral gene expression during Kaposi's sarcoma .

The YTHDF2 reader protein proved particularly important, as its depletion eliminated lytic entry and virion production. ... In addition, independent siRNAs (Qiagen SI04174534 targeting YTHDF2, Qiagen SI00764778 targeting YTHDF3 and Qiagen SI03650318S2 Fig ...

Loss of YTHDF2-mediated m 6 A-dependent mRNA clearance facilitates hematopoietic stem cell regeneration | Cell Resear

Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid Leukemia Jasmin Paris, Marcos Morgan, Joana Campos ...

Targeting the RNA m(6)A reader YTHDF2 selectively compromises cancer stem cells in acute myeloid leukem

show that the mRNA m6A reader YTHDF2 is overexpressed in a broad spectrum of human AML and is required for disease ... Morgan M, Campos J, Spencer GJ, Shmakova A, Ivanova I, et al. Targeting the RNA m(6)A reader YTHDF2 selectively . Journal ...

Publications | Marcos Morgan L

List of publications from Marcos Morgan. Research includes understanding the role of RNA modifications such as 3' terminal uridylation and m6A methylation in different systems with particular emphasis on spermatogenesis and oogenesis. ... Marcos MORGAN ...